Health Minister Aaron Motsoaledi says he is confident that the rollout of the antiretroviral medication, Lenacapavir, will greatly help combat South Africa’s HIV and Aids epidemic.

The new long-acting HIV prevention injection endorsed by the World Health Organisation is administered twice a year.

Clinical trials have shown it to be highly effective, providing almost complete protection against HIV infections when administered as recommended at six-month intervals.

It is expected to be rolled out in April next year at over 300 public clinics in high-infection areas nationwide.

Motsoaledi was speaking at a roundtable on the country’s readiness to roll out the drug.

lenacapavir presents a true breakthrough in prevention science and service delivery. This six-month dosing schedule has the potential to overcome many of the barriers we have seen with daily oral prep. It offers greater discretion, convenience and likely much better adherence for users, especially with people who struggle with taking a pill everyday or making frequent clinic visits.”

Motsoaledi confident Lenacapavir will boost the fight against HIV/AIDS in South Africa

Minister Dr Aaron Motsoaledi with the Deputy Minister, Dr Joe Phaahla, Director General, Dr Sandile Buthelezi and SANAC CEO, Dr Thembisile Xulu, arriving this morning for the National Roundtable on Lenacapavir Access and Sustainability in South Africa, held in Kempton Park. pic.twitter.com/5dyOAYCyCF

— National Department of Health (@HealthZA) October 14, 2025